Here’s a link to a Electro-Harmonix’s “Effectology” page where they show you tons of ways to create all sorts of sounds samples using only a guitar and their effect pedals.  Click Here to check out all the different sounds you can make.

No Synths, computers, samplers, or midi controls, just old school strings and stompboxes.  http://www.ehx.com/products/big-muff-pi